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The cover shows a three-dimensional construction of a Coxsackie B virus, a type of enterovirus. These viruses typically cause a mild respiratory illness but they also have properties that allow them to spread to the pancreatic islets and cause beta cell damage. Their role in the pathogenesis of type 1 diabetes has been suspected but not confirmed, although in recent years the link has been supported by accumulating scientific evidence. Of all the high-quality papers that appear in this month’s issue I want to share with you some articles that I find to be of particular interest.
These will be featured ‘up front’ in the print issue and here on our website. Bachmann and Wang review the current and potential uses of biomarkers of cardiovascular disease in individuals with diabetes. At present, some individual biomarkers and combinations of biomarkers produce modest improvements in cardiovascular risk prediction in people with diabetes beyond traditional cardiovascular risk factors. The figures from this review are available as a downloadable slideset. At present no novel biomarkers of diabetic kidney disease are in routine use clinically or in trials, despite large-scale research efforts in this area. Colhoun and Marcovecchio review the current status of prognostic biomarkers. They first consider the role of routine clinical data in predicting who will develop kidney disease and whose disease will rapidly progress.
Ute Schaefer-Graf, Angela Napoli, Christopher J. The Diabetic Pregnancy Study Group, a study group of the EASD, recently reviewed progress and set new directions for research and clinical practice improvements for women affected by diabetes in pregnancy. There has been a progressive increase in the prevalence of early-onset type 2 diabetes mellitus, with some evidence suggesting that it may be a more aggressive form of diabetes. Huo et al seek to understand the impact of age at diagnosis on mortality. Wahed, Chiara Dalla Man, Francesca Piccinini, Claudio Cobelli, Ronald L.
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Rates of type 2 diabetes remission are high following gastric bypass. Caring for pregnant women whose diabetes antedates pregnancy: is there room for improvement? Abdullah, Renata Pomahačová, Veselin Boyadzhiev, Lesby E. Godoy, Thiruvengadam Vasanthi, Ramlah Al Saif, Aria Setoodeh, Amirreza Haghighi, Alireza Haghighi, Yomna Shaalan, International Neonatal Diabetes Consortium, Andrew T. Visser, Lenie van Rossem, Douwe H. Rebholz, Bing Yu, Zihe Zheng, Patrick Chang, Adrienne Tin, Anna Köttgen, Lynne E.